Kyrana Tsapkini, PhD
Associate Professor, Neurology 
Johns Hopkins School of Medicine

Zoom: https://arizona.zoom.us/j/88471852251
 

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Neuromodulation-induced neuroplasticity in primary progressive aphasia: mechanisms, predictors and challenges

Abstract: Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized predominantly by the gradual impairment of language abilities. In this talk, I will explore the efficacy of combining transcranial direct current stimulation (tDCS) with language therapy to enhance language outcomes but also how we can predict and personalize treatment. I will examine clinical, imaging and life-style predictors or responsiveness to tDCS as well as mechanisms such as functional connectivity and neurotransmitter changes. I will then address what we have learned and what we can learn about neuroplasticity in the context of neurodegeneration and how this knowledge can affect our treatment approaches and especially neuromodulation.